In "Prognosis Do Over," Amy Andrews presents readers with a heartwarming blend of romance, drama, and medical challenges set against the fast-paced backdrop of emergency medicine. This novel, part of Andrews' larger body of work in romantic fiction, stands out for its meticulous attention to medical detail, engaging character development, and a plot that keeps readers emotionally invested until the last page.

The story follows Dr. Mia McKenzie, a dedicated and skilled emergency room physician whose life is thrown into turmoil following a surprising diagnosis that challenges her professional identity and personal resilience. Across from her is Dr. Jack Ryder, an equally competent yet charming colleague who struggles with his own shadows. The narrative weaves these two lives together in a dance of personal and professional intersections, making for a compelling read.

Andrews' portrayal of Mia is particularly compelling. As the protagonist, Mia is portrayed with depth; she's not just a doctor but also a woman grappling with profound life questions and vulnerabilities. Her journey through the initial shock of her diagnosis to her fight back to normalcy and success provides a sensitive exploration of the personal impact of life-altering medical news. The character's emotional and professional conflicts are drawn with a realism that many readers in the healthcare profession, and others facing personal battles, will find both relatable and inspiring.

Similarly, Jack’s character development adds layers to the narrative. His persona provides a balance to Mia's intensity. He is affable and supportive, but not without his complications, making him a well-rounded counterpart. The dynamic between Mia and Jack evolves beautifully throughout the book, swinging from professional camaraderie to deep personal connection. This relationship serves as the book’s emotional core, and Andrews skillfully captures the complexities of a romance born in such intense circumstances without it feeling forced or unrealistic.

The medical backdrop of "Prognosis Do Over" is one of its strongest aspects. Andrews' attention to detail paints a vivid picture of the highs and lows of hospital life. The emergency room scenes are particularly well-crafted, filled with the adrenaline of critical cases mixed with the mundanity of routine checks. These scenes enhance the authenticity of the narrative, grounding the personal drama in a tangible world that’s easy for the reader to visualize.

Moreover, Andrews does not shy away from the technical aspects of medicine. The jargon and procedures are presented in an accessible manner that doesn’t overwhelm the lay reader but will satisfy those with a background in healthcare. This careful balance ensures that the story remains engaging without becoming bogged down by excessive detail.

One of the novel’s strengths is surely its pacing. Andrews orchestrates a well-timed flow of events, knowing when to dive deep into emotional introspection and when to push the plot forward. This pacing keeps the tension and interest alive, making the book hard to put down particularly in the latter half as stakes in both personal and professional fronts escalate.

"Prognosis Do Over" is also commendable for how it handles themes such as resilience, vulnerability, and the impact of friendship and love. The supporting characters are notably well-developed, from the ER team to the patients, each adding richness to the setting. These interactions underscore the message that no one navigates life’s trials alone – a poignant reminder stitched seamlessly into the fabric of the story.

However, the novel is not without its minor flaws. At times, the emotional dialogues can feel slightly repetitive, especially in the middle sections where Mia’s inner turmoil could have been condensed without losing impact. Also, some readers might find the ending a bit predictable, albeit satisfying. Yet, these are small critiques in an otherwise engaging narrative.

In conclusion, "Prognosis Do Over" by Amy Andrews is a heartfelt, stirring read that balances the drama of an emergency room with the tenderness of a blossoming romance. For those who enjoy medical dramas, or stories about personal resilience and romance against the odds, this book promises not just entertainment but also emotional enrichment. Andrews proves once again that she can pulse the heart and engage the mind, making this more than just a simple love story. It is, at its core, a celebration of life’s unexpected second chances.